Components of the Combination Tablet

1. Telmisartan 40 mg

• Class: Angiotensin II Receptor Blocker (ARB)
• Mechanism of Action: Blocks the action of angiotensin II, causing blood vessels to relax and widen.
• Uses: Treats high blood pressure and reduces stroke risk in certain patients.
• Side Effects: Dizziness, headache, fatigue, hyperkalemia, renal impairment.
• Precautions: Monitor kidney function and potassium levels; not recommended during pregnancy.

2. Amlodipine 5 mg

• Class: Calcium Channel Blocker (CCB)
• Mechanism of Action: Prevents calcium from entering cells in the heart and blood vessels, causing relaxation and widening of the vessels.
• Uses: Treats high blood pressure and angina (chest pain).
• Side Effects: Swelling of the legs/ankles, dizziness, fatigue, palpitations, flushing.
• Precautions: Monitor blood pressure regularly; use with caution in severe heart conditions.

3. Hydrochlorothiazide 12.5 mg

• Class: Thiazide Diuretic
• Mechanism of Action: Promotes sodium and water excretion, reducing blood volume and pressure.
• Uses: Treats high blood pressure and fluid retention in conditions like heart failure and kidney disorders.
• Side Effects: Increased urination, dizziness, electrolyte imbalances, dehydration, elevated blood sugar levels.
• Precautions: Monitor electrolyte levels and kidney function; ensure adequate hydration.

Combined Benefits

**1. Enhanced Blood Pressure Control: Each component works through different mechanisms:

• Telmisartan helps relax blood vessels.
• Amlodipine prevents calcium from tightening the blood vessels.
• Hydrochlorothiazide reduces fluid volume.